منابع مشابه
Toxicokinetic models and their applications
In this paper toxicokinetics was examined. Chemical distribution, absorption and elimination in the living organism were investigated. The aim of this paper kinetic of toxic substance during exposure in a biological system was studied. Several toxicokinetic models using physiological and biochemical parameters were derived. Physiologically based toxicokinetic models and similar pharmacokinetic ...
متن کاملInterindividual and interoccasion variability of toxicokinetic parameters in population models
The determination of toxicokinetic parameters is an essential component in the risk assessment of potential harmful chemicals. It’s a first step to analyse the processes which are involved in the development of DNA adducts and might therefore lead to the development of cancer. The complete research depends on investigations with animals in vivo and in vitro, so that a critical step is the extra...
متن کاملBayesian analysis of physiologically based toxicokinetic and toxicodynamic models.
Physiologically based toxicokinetic (PBTK) and toxicodynamic (TD) models of bromate in animals and humans would improve our ability to accurately estimate the toxic doses in humans based on available animal studies. These mathematical models are often highly parameterized and must be calibrated in order for the model predictions of internal dose to adequately fit the experimentally measured dos...
متن کاملDeveloping confidence in risk assessments based on physiological toxicokinetic models.
Copyright © 2007 AHC The aim of this study was to investigate the immunolocalization and the existence of thyroid hormone receptors (THR) (alpha1/alpha2) in rat uterus and oviduct. For this purpose 6 female Wistar albino rats found in estrous period were used. Tissue samples fixed in 10% neutral formalin were examined immunohistochemically. Sections were incubated with primary mouse-monoclonal ...
متن کاملPerformance Evaluation of Dynamic Modulus Predictive Models for Asphalt Mixtures
Dynamic modulus characterizes the viscoelastic behavior of asphalt materials and is the most important input parameter for design and rehabilitation of flexible pavements using Mechanistic–Empirical Pavement Design Guide (MEPDG). Laboratory determination of dynamic modulus is very expensive and time consuming. To overcome this challenge, several predictive models were developed to determine dyn...
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ژورنال
عنوان ژورنال: Environmental Toxicology and Chemistry
سال: 1990
ISSN: 0730-7268,1552-8618
DOI: 10.1002/etc.5620090201